Center for Organic Synthesis
Research
Active Research Projects
-
Research plans designed to monitor protein small molecule (substrate) interactions. This work spans from pure synthetic organic chemistry to qualitative and quantitative monitoring to biochemical reactions. Our research focuses on the synthesis of Bio-organic substrates- (Biomarkers)- Acyl carnitine, and Acyl Coenzyme A, for clinical diagnosis, and the investigation of the reaction mechanism, and intermediates characterization of specific metabolic pathways. Furthermore, we aim to investigate the protein-protein interaction and its influence in diseases progression. Recent efforts focused on critical needs in the area of microbiome biology, and more specifically synthesize and characterize microbe-derived metabolites (xenometabolites). This involves custom synthesis and spectroscopic characterization and full quantification by mass spectrometry of xenometabolites or xenometabolite-derivatives.
-
Recent research projects focused on the synthesis of specialty-functionalized biodegradable photo polymers and the development of a photochemical strategy for cross-linking biopolymers for scaffolds, coatings and prostheses. We developed a series of phosphine oxides photo initiators that can achieve compatibility with aqueous media with improved performance. This type of initiator is promising in biomedical applications, specifically for Orthopedic, clinical dentistry and bone tissue engineering, since it is relatively nontoxic and may become incorporated innocuously into organic matrices and tissues.
Excellence in Undergraduate Research
I began working with Dr. Sobhi in the summer of 2019 in the Center for Organic Synthesis in collaboration with the University of Maryland, School of Medicine. This opportunity has opened many doors for me, as well as meet some amazing people. During our time in the lab, I have since been able to gain a better understanding of techniques used in chemical analysis such as, Infrared Spectrometry, Mass Spectrometry, and Nuclear Magnetic Resonance. Mastering these methods have shed some light on new interests and exposed me to new concentrations that I plan to use when furthering my education post-graduation. I am very grateful for this opportunity I was given and the experience I have gained through Dr. Sobhi.
Amanda Robinson, Chemistry Major
