Student Presentations

Student Presentations

Ms. Mariah Benjamin

Research Student

Biochemical, morphological and gene expression modulation induced by oxidant challenge to the neutral retina: Possible prevention by pyruvate.

Coppin State University Fourth Annual Science Symposium
September 22, 2016

Faculty Mentor: Dr. Kavita Hegde

Abstract:
Excessive generation of reactive oxygen species (ROS) and consequent oxidative stress has been known to be involved in the pathogenesis of many retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD), the two most common vision-impairing and blinding diseases of the retina, especially in Western countries. Although both these diseases have several contributing factors in their pathogenesis, one of the common aberrations seen in both, and several other retinal diseases, is oxidative damage and consequent degeneration of the neural retina with resulting vision loss. Current treatments for these diseases, especially AMD, have limited effectiveness in terms of restoring vision and halting progressive vision loss. It is hence considered necessary to continue to develop newer treatments or novel compounds which have the ability to effectively thwart the degenerative process and preserve useful vision. Studies are currently underway to test the effectiveness of pyruvate, a highly effective scavenger of ROS, in preventing biochemical damage to the neural retina. In addition, further studies are also planned to test whether pyruvate can regulate the redox status of the tissue through modulating the transcription and activity of Nrf2 and the expression of Nrf2 downstream genes in the neural retina when presented with oxidant challenge.

 

Chisomaga Madufor

Research student

Poster Presentation: Biochemical and Nrf2-inducible Gene Expression Studies in ROS-exposed Retina and their Modulation by Pyruvate

Morgan State University Undergraduate and Graduate Research Conference
April 13, 2017

Faculty Mentor: Dr. Kavita Hegde